Structure of PDB 6vvo Chain C

Receptor sequence
>6vvoC (length=312) Species: 9606 (Homo sapiens) [Search protein sequence]
NLPWVEKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLYGPPGTGKTS
TILACAKQLYKDKEFGSMVLELNASDDIDIIRGPILSFASTRTIFKKGFK
LVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCT
RFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL
QSTNMAFGKVTEETVYTCTGHPLKSDIANILDWMLNQDFTTAYRNITELK
TLKGLALHDILTEIHLFVHRVDFPSSVRIHLLTKMADIEYRLSVGTNEKI
QLSSLIAAFQVT
3D structure
PDB6vvo Structure of the human clamp loader bound to the sliding clamp: a further twist on AAA+ mechanism
ChainC
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS C V23 R27 P28 L34 I35 G63 T64 G65 K66 T67 S68 R185 M213 R214 V5 R9 P10 L16 I17 G45 T46 G47 K48 T49 S50 R165 M193 R194
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0019899 enzyme binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0032508 DNA duplex unwinding
GO:1900264 positive regulation of DNA-directed DNA polymerase activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005663 DNA replication factor C complex
GO:0031390 Ctf18 RFC-like complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6vvo, PDBe:6vvo, PDBj:6vvo
PDBsum6vvo
PubMed
UniProtP40937|RFC5_HUMAN Replication factor C subunit 5 (Gene Name=RFC5)

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