Structure of PDB 6voy Chain C

Receptor sequence

>6voyC (length=276) Species: 11927,273057

PSPAELHSFTHCGQTALTLQGATTTEASNILRSCHACRKNNPQHQMPRGH
IRRGLLPNHIWQGDITHFKYKNTLYRLHVWVDTFSGAISATQKRKETSSE
AISSLLQAIAYLGKPSYINTDNGPAYISQDFLNMCTSLAIRHTTHVPYNP
TSSGLVQRSNGILKTLLYKYFTDKPDLPMDNALSIALWTINHLNVLTNCH
KTRWQLHHSPRLQPIPETRSLSNKQTHWYYFKLPGLNSRQWKGPQEALQE
AAGAALIPVSASSAQWIPWRLLKRAA

3D structure

• PDB: 6voy Structural basis of host protein hijacking in human T-cell leukemia virus integration.
• Chain: C
• Resolution: 3.7 Å

Enzymatic activity

• Enzyme Commision number:
  2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.26.4: ribonuclease H.
  3.4.23.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	C	P149 Q156 R157 K163	P150 Q157 R158 K164
BS02	dna	C	G48 H49 I50 R51 V145 R157 L220 A251 W265	G49 H50 I51 R52 V146 R158 L221 A252 W266
BS03	dna	C	K94 E95 Q128	K95 E96 Q129
BS04	dna	C	Q42 Q44	Q43 Q45
BS05	dna	C	D120 N121 Y147	D121 N122 Y148
BS06	ZN	C	H6 H10 C33 C36	H7 H11 C34 C37

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0004521 RNA endonuclease activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0015074 DNA integration

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6voy, PDBe:6voy, PDBj:6voy
• PDBsum: 6voy
• PubMed: 32561747
• UniProt: P14078;
  P39476|DN7D_SACS2 DNA-binding protein 7d (Gene Name=sso7d)