Structure of PDB 6viz Chain C

Receptor sequence
>6vizC (length=106) Species: 9606 (Homo sapiens) [Search protein sequence]
TNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGT
IKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQ
KINELP
3D structure
PDB6viz Discovery ofN-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain.
ChainC
Resolution2.391 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QYY C W81 P82 Q85 V87 D88 K91 L92 N140 I146 W22 P23 Q26 V28 D29 K32 L33 N81 I87 MOAD: Ki=120nM
BindingDB: Ki=120nM
External links
PDB RCSB:6viz, PDBe:6viz, PDBj:6viz
PDBsum6viz
PubMed32324999
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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