Structure of PDB 6vax Chain C

Receptor sequence
>6vaxC (length=611) Species: 9606 (Homo sapiens) [Search protein sequence]
QYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAA
QGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPAAVVEL
ENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHT
LYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTV
VATGGYGRTYFSCTSAHTSTGDGTAMITRAGLPCQDLEFVQFHPTGIYGA
GCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIRE
GRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVL
PTVHYNMGGIPTNYKGQVLRHVNGQDQIVPGLYACGEAACASVHGANRLG
ANSLLDLVVFGRACALSIEESCRPGDKVPPIKPNAGEESVMNLDKLRFAD
GSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCGKISKLYGDLKHLKTFD
RGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVRIDE
YDYSKPIQGQQKKPFEEHWRKHTLSYVDVGTGKVTLEYRPVIDKTLNEAD
CATVPPAIRSY
3D structure
PDB6vax The roles of SDHAF2 and dicarboxylate in covalent flavinylation of SDHA, the human complex II flavoprotein.
ChainC
Resolution2.59 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F173 Q294 H296 L306 E309 R312 R340 H407 Y408 R451
Catalytic site (residue number reindexed from 1) F120 Q241 H243 L253 E256 R259 R287 H354 Y355 R398
Enzyme Commision number 1.3.5.1: succinate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD C G68 A69 G70 T91 K92 L93 S98 H99 T100 A103 G105 A221 A255 T256 G257 T267 D275 H407 Y408 E440 A454 S456 L457 L460 G15 A16 G17 T38 K39 L40 S45 H46 T47 A50 G52 A168 A202 T203 G204 T214 D222 H354 Y355 E387 A401 S403 L404 L407
BS02 OAA C R340 H407 R287 H354
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008177 succinate dehydrogenase (quinone) activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006105 succinate metabolic process
GO:0006121 mitochondrial electron transport, succinate to ubiquinone
GO:0007399 nervous system development
GO:0022900 electron transport chain
GO:0022904 respiratory electron transport chain
GO:0042776 proton motive force-driven mitochondrial ATP synthesis
Cellular Component
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0045273 respiratory chain complex II (succinate dehydrogenase)

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Molecular Function
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Cellular Component
External links
PDB RCSB:6vax, PDBe:6vax, PDBj:6vax
PDBsum6vax
PubMed32887801
UniProtP31040|SDHA_HUMAN Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Gene Name=SDHA)

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