Structure of PDB 6v65 Chain C

Receptor sequence
>6v65C (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIRKHKE
3D structure
PDB6v65 Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.
ChainC
Resolution2.763 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP C G15 K16 S17 A18 Y32 P34 T35 G60 K117 D119 S145 A146 G15 K16 S17 A18 Y32 P34 T35 G60 K117 D119 S145 A146
BS02 MG C S17 T35 D57 S17 T35 D57
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6v65, PDBe:6v65, PDBj:6v65
PDBsum6v65
PubMed32697994
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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