Structure of PDB 6uya Chain C

Receptor sequence
>6uyaC (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
DTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVA
VKKLKQQFDQEIKVMAKCQHENLVELLGFSSDDLCLVYVYMPNGSLLDRL
SCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFT
AKISDFGLARATVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEI
ITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMY
SVASQCLHEKKNKRPDIKKVQQLLQEMT
3D structure
PDB6uya Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity.
ChainC
Resolution1.74 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D311 K313 A315 N316 D329 T351
Catalytic site (residue number reindexed from 1) D137 K139 A141 N142 D155 T171
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QL7 C I185 M192 G193 V200 A211 Y262 Y264 M265 P266 G268 R273 T280 L318 I24 M31 G32 V39 A50 Y88 Y90 M91 P92 G94 R99 T106 L144 BindingDB: Ki=1.50nM,IC50=0.190000nM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6uya, PDBe:6uya, PDBj:6uya
PDBsum6uya
PubMed32184965
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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