Structure of PDB 6usa Chain C

Receptor sequence
>6usaC (length=249) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
EASRLGPVFDSCRANNRAALIGYLPTGYPDVPASVAAMTALVESGCDIIE
VGVPYSDPGMDGPTIARATEAALRGGVRVRDTLAAVEAISIAGGRAVVMT
YWNPVLRYGVDAFARDLAAAGGLGLITPDLIPDEAQQWLAASEEHRLDRI
FLVAPSSTPERLAATVEASRGFVYAASSQAAPELVGRVKAVSDIPVGVGL
GVRSRAQAAQIAQYADGVIVGSALVTALTEGLPRLRALTGELAAGVRLG
3D structure
PDB6usa Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase.
ChainC
Resolution2.406 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E57 D68 Y181
Catalytic site (residue number reindexed from 1) E50 D61 Y174
Enzyme Commision number 4.2.1.20: tryptophan synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PZJ C G66 M67 D136 G59 M60 D129
Gene Ontology
Molecular Function
GO:0004834 tryptophan synthase activity
GO:0016829 lyase activity
Biological Process
GO:0000162 tryptophan biosynthetic process
GO:0006568 tryptophan metabolic process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6usa, PDBe:6usa, PDBj:6usa
PDBsum6usa
PubMed31930594
UniProtP9WFY1|TRPA_MYCTU Tryptophan synthase alpha chain (Gene Name=trpA)

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