Structure of PDB 6uqe Chain C

Receptor sequence

>6uqeC (length=578) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

MENFTTNLNQLARVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGV
GKTAIAEGLAWRIVQGDVPEVMADCTIYSLDIGSLLAGTKYRGDFEKRFK
ALLKQLEQDTNSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKIRV
IGSTTYQEFSNIFEKDRALARRFQKIDITEPSIEETVQIINGLKPKYEAH
HDVRYTAKAVRAAVELAVKYINDRHLPDKAIDVIDEAGARARLMPVSKRK
KTVNVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKMLVFGQDKAIE
ALTEAIKMARAGLGHEHKPVGSFLFAGPTGVGKTEVTVQLSKALGIELLR
FDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDAVIKHPHAVLLLDEIEK
AHPDVFNILLQVMDNGTLTDNNGRKADFRNVVLVMTTNAGVRETERKSIG
LIHQDNSTDAMEEIKKIFTPEFRNRLDNIIWFDHLSTDVIHQVVDKFIVE
LQVQLDQKGVSLEVSQEARNWLAEKGYDRAMGARPMARVIQDNLKKPLAN
ELLFGSLVDGGQVTVALDKEKNELTYGF

3D structure

PDB

6uqe Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.

Chain

Resolution

3.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	C	K258 Y259 A295 A296	K90 Y91 A127 A128
BS02	peptide	C	G539 Y540 V541	G371 Y372 V373
BS03	AGS	C	I189 G217 V218 G219 K220 T221 A222 I357	I21 G49 V50 G51 K52 T53 A54 I189
BS04	AGS	C	V460 F461 T497 G498 V499 G500 K501 T502 E503 N606 F665 A701 R702	V292 F293 T329 G330 V331 G332 K333 T334 E335 N438 F497 A533 R534
BS05	AGS	C	R339 R340	R171 R172

Gene Ontology

	Molecular Function
GO:0005524	ATP binding
GO:0016887	ATP hydrolysis activity

View graph for
Molecular Function

External links

PDB	RCSB:6uqe, PDBe:6uqe, PDBj:6uqe
PDBsum	6uqe
PubMed	32313240
UniProt	P0ABH9\|CLPA_ECOLI ATP-dependent Clp protease ATP-binding subunit ClpA (Gene Name=clpA)

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