Structure of PDB 6uml Chain C

Receptor sequence
>6umlC (length=338) Species: 9606 (Homo sapiens) [Search protein sequence]
NFDTSLPTSHTYLFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFH
PQEVSMVRNLIQKDRTFAVLYSEAQFGTTAEIYAYREEQDFGIEIVKVKA
IGRQRFKQAKVQILPECVLPSTMSAVQLESLNKCQIFSYKWWQKYQKRKF
HCANLTSWPRWLYSLYDAETLMDRIKKQLREWDLPSNPIDFSYRVAACLP
IDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFS
LSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVA
QCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIP
3D structure
PDB6uml Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex.
ChainC
Resolution3.58 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C N351 H353 H357 I371 H397 N262 H264 H268 I282 H308
BS02 ZN C C323 C326 C391 C394 C234 C237 C302 C305
BS03 Y70 C N351 P352 H353 H378 W380 W386 W400 F402 N262 P263 H264 H289 W291 W297 W311 F313 BindingDB: IC50=2000nM
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0044325 transmembrane transporter binding
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0030177 positive regulation of Wnt signaling pathway
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031334 positive regulation of protein-containing complex assembly
GO:0034766 negative regulation of monoatomic ion transmembrane transport
GO:0035641 locomotory exploration behavior
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1902607 negative regulation of large conductance calcium-activated potassium channel activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0048471 perinuclear region of cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6uml, PDBe:6uml, PDBj:6uml
PDBsum6uml
PubMed32251415
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

[Back to BioLiP]