Structure of PDB 6u88 Chain C

Receptor sequence
>6u88C (length=611) Species: 10116 (Rattus norvegicus) [Search protein sequence]
FDRDRLFSVVSRGVPEELTGLLEYLRWNSKYLTDSAYTEGSTGKTCLMKA
VLNLQDGVNACIMPLLQIDKDSGNPKLLVNAQCTDEFYQGHSALHIAIEK
RSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWD
VVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGL
LQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQREFSGPYQ
PLSRKFTEWCYGPVRVSLYDLSSVDSWEKNSVLEIIAFHCKSPNRHRMVV
LEPLNKLLQEKWDRLVSRFFFNFACYLVYMFIFTVVAYHQPFGESMLLLG
HILILLGGIYLLLGQLWYFWRRRLFIWISFMDSYFEILFLLQALLTVLSQ
VLRFMETEWYLPLLVLSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDL
LRFLLVYLVFLFGFAVALVSLSREARPYRSILDASLELFKFTIGMGELAF
QEQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNHVADNSWSIWKL
QKAISVLEMENGYWWCRRKKHREGRLLKVGPDERWCFRVEEVNWAAWEKT
LPTLSEDPSGP
3D structure
PDB6u88 Molecular mechanism of TRPV2 channel modulation by cannabidiol.
ChainC
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P0T C L631 Y634 V635 L519 Y522 V523
BS02 P0T C I533 L537 F540 L541 Y544 L637 M640 I446 L450 F453 L454 Y457 L525 M528
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell population proliferation
GO:0009266 response to temperature stimulus
GO:0045773 positive regulation of axon extension
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0090280 positive regulation of calcium ion import
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030424 axon
GO:0032584 growth cone membrane
GO:0042470 melanosome
GO:0044295 axonal growth cone
GO:0044297 cell body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6u88, PDBe:6u88, PDBj:6u88
PDBsum6u88
PubMed31566564
UniProtQ9WUD2|TRPV2_RAT Transient receptor potential cation channel subfamily V member 2 (Gene Name=Trpv2)

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