Structure of PDB 6u6z Chain C

Receptor sequence
>6u6zC (length=438) Species: 9606 (Homo sapiens) [Search protein sequence]
GKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCH
HLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHR
RAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTK
LTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKRE
DYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDDHVSFYCKTAPNRAI
AEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQD
3D structure
PDB6u6z Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
ChainC
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C K116 V117 I118 H125 D137 R145 K2 V3 I4 H11 D23 R31
BS02 dna C Y155 V156 H376 V378 R451 Y41 V42 H255 V257 R330
BS03 ZN C H167 H206 D207 D311 H53 H92 D93 D190
External links
PDB RCSB:6u6z, PDBe:6u6z, PDBj:6u6z
PDBsum6u6z
PubMed33531504
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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