Structure of PDB 6u6y Chain C

Receptor sequence
>6u6yC (length=431) Species: 9606 (Homo sapiens) [Search protein sequence]
MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNNGIDVAKWDYFARDCHHL
GIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRA
YQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLT
DNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDY
ESLPKEVASAKPKVLLDVKLKAEDFIVDVINMVSFYCKTAPNRAIEQLIR
VYCKKVDRKSLYAARQYFVQWCADRNFTKPQ
3D structure
PDB6u6y Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
ChainC
Resolution2.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna C K116 V117 I118 D137 R145 K2 V3 I4 D23 R31
BS02 rna C Y155 V156 H376 V378 R451 Y41 V42 H253 V255 R328
BS03 ZN C H167 H206 D207 H53 H92 D93
BS04 DTP C Q149 R164 H215 Y315 D319 Y374 Q35 R50 H101 Y192 D196 Y251
External links
PDB RCSB:6u6y, PDBe:6u6y, PDBj:6u6y
PDBsum6u6y
PubMed33531504
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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