Structure of PDB 6u6x Chain C

Receptor sequence
>6u6xC (length=376) Species: 9606 (Homo sapiens) [Search protein sequence]
TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHN
RFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPF
SHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEE
DICFIKEQIVGPRPENKSFLYEIVSNIDVAKWDYFARDCHHLGIQNNFDY
KRFIKFARVCEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKAD
DYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREI
LKQIEYRNLFKYVGETQPIKREDYESLPKEVASAAEDFIVDVINQLIRVY
CKKVDRKSLYAARQYFVQWCADRNFT
3D structure
PDB6u6x Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
ChainC
Resolution2.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C K116 V117 I118 H125 D137 R145 K3 V4 I5 H12 D24 R32
BS02 dna C Y155 V156 R371 R372 H376 K377 R451 Y42 V43 R227 R228 H232 K233 R307
BS03 ZN C H167 D207 H54 D94
External links
PDB RCSB:6u6x, PDBe:6u6x, PDBj:6u6x
PDBsum6u6x
PubMed33531504
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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