Structure of PDB 6u63 Chain C

Receptor sequence
>6u63C (length=138) Species: 9606 (Homo sapiens) [Search protein sequence]
EDELYRQSLEIISRYLREQATGAGATSRKALETLRRVGDGVQRNHETAFQ
GMLRKLDIDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTIN
QESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH
3D structure
PDB6u63 Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins.
ChainC
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q0D C M231 V253 R263 F270 M52 V71 R81 F88 BindingDB: Ki=220nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:6u63, PDBe:6u63, PDBj:6u63
PDBsum6u63
PubMed31971799
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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