Structure of PDB 6txa Chain C

Receptor sequence

>6txaC (length=480) Species: 9606 (Homo sapiens) [Search protein sequence]

MKVINDPIHGHIELHPLLVRIINTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGPLESLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARD
CHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSL
HRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAY
TKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIK
REDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVS
FYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYF
VQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

6txa Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Chain

Resolution

2.853 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	XG4	C	V156 F157 R372 H376 K377	V42 F43 R253 H257 K258
BS02	XG4	C	R333 R352 K354 N358 K523	R214 R233 K235 N239 K404
BS03	FE	C	H167 H206 D207 D311	H53 H92 D93 D192
BS04	MG	C	D207 H233	D93 H119
BS05	XG4	C	Q149 L150 R164 D207 H215 H233 D311 K312 Y315 D319 R366 Y374 Q375	Q35 L36 R50 D93 H101 H119 D192 K193 Y196 D200 R247 Y255 Q256
BS06	CZF	C	K116 V117 I118 N137 R145	K2 V3 I4 N23 R31
BS07	CZF	C	Y155 V156 V378 R451	Y41 V42 V259 R332

External links

PDB	RCSB:6txa, PDBe:6txa, PDBj:6txa
PDBsum	6txa
PubMed	32576829
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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