Structure of PDB 6trx Chain C

Receptor sequence
>6trxC (length=841) Species: 9606 (Homo sapiens) [Search protein sequence]
LEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSD
RIYYLAMSNRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQYSREEELLR
ERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNL
VETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNEL
ANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEEN
DESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRI
IDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVL
ISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVF
PQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKC
PIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVS
YVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPE
DDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDL
QPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRG
SCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSY
GGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGY
YLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYD
LQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKV
3D structure
PDB6trx Aerosol-based ligand soaking of reservoir-free protein crystals.
ChainC
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Y669 S755 Y756 D833 H865
Catalytic site (residue number reindexed from 1) Y613 S699 Y700 D777 H809
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TMO C H315 T317 H259 T261
BS02 TMO C T317 R324 R325 T261 R268 R269
BS03 9XH C R160 E275 E276 Y669 S755 Y756 V781 W784 Y787 Y791 N835 R104 E219 E220 Y613 S699 Y700 V725 W728 Y731 Y735 N779 BindingDB: IC50=14nM
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0043069 negative regulation of programmed cell death
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6trx, PDBe:6trx, PDBj:6trx
PDBsum6trx
PubMed34188616
UniProtQ6V1X1|DPP8_HUMAN Dipeptidyl peptidase 8 (Gene Name=DPP8)

[Back to BioLiP]