Structure of PDB 6trw Chain C

Receptor sequence
>6trwC (length=838) Species: 9606 (Homo sapiens) [Search protein sequence]
LEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSD
RIYYLAMSRENTLFYSEIPKTINRAAVLMLSWKPLLDLYSREEELLRERK
RIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVET
SCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANM
EEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDES
EVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDV
IDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISP
ELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQS
HEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIK
EEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVN
PGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDP
TCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPG
KKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCH
RGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGY
LSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLG
SVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQI
YPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKV
3D structure
PDB6trw Aerosol-based ligand soaking of reservoir-free protein crystals.
ChainC
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y669 S755 Y756 D833 H865
Catalytic site (residue number reindexed from 1) Y610 S696 Y697 D774 H806
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C M76 R160 E275 E276 Y669 W754 S755 V781 W784 Y787 Y791 H865 S866 I867 R868 P870 Y876 M29 R101 E216 E217 Y610 W695 S696 V722 W725 Y728 Y732 H806 S807 I808 R809 P811 Y817
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0043069 negative regulation of programmed cell death
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6trw, PDBe:6trw, PDBj:6trw
PDBsum6trw
PubMed34188616
UniProtQ6V1X1|DPP8_HUMAN Dipeptidyl peptidase 8 (Gene Name=DPP8)

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