Structure of PDB 6thq Chain C

Receptor sequence
>6thqC (length=296) Species: 999630 (Thermoproteus uzoniensis 768-20) [Search protein sequence]
SMKVWLDGRLVDEEEAKVTVLSPSLNYGFGVFEGIRAYWNGENLYVFRLR
DHMERLLRSAKIIGLDVPYTAEELSKAVVETVRANGFKEDLYIRPVAYIS
KPQISLDVRGLQASVAIAAIPFGKYLKVEGVRAAVVSWRRVHTSMMPVMA
KATGIYLNSIMAAVEARARGYDEAIMLNAEGKVVEGSGENIFIVRRGVLM
TPPLEDGILEGITRETVISIAGDLGIPLLEKSITREELYAADEAFFVGTA
AEITPIIEIDGRVLQRGPITQKIAETYRRIVLGKEEKYLPWLTPVY
3D structure
PDB6thq Three-Dimensional Structure of Branched-Chain Amino Acid Transaminase from Thermoproteus uzoniensis in Complex with L-Norvaline
ChainC
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F31 K150 E184 L208
Catalytic site (residue number reindexed from 1) F32 K151 E185 L209
Enzyme Commision number 2.6.1.42: branched-chain-amino-acid transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP C R54 K150 Y155 E184 E188 L208 G210 I211 T212 T248 R55 K151 Y156 E185 E189 L209 G211 I212 T213 T249
BS02 PY5 C R54 Y91 K150 Y155 E184 G187 E188 N189 G210 I211 T212 G247 T248 A249 R55 Y92 K151 Y156 E185 G188 E189 N190 G211 I212 T213 G248 T249 A250
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004084 branched-chain-amino-acid transaminase activity
GO:0008483 transaminase activity
GO:0052654 L-leucine-2-oxoglutarate transaminase activity
GO:0052655 L-valine-2-oxoglutarate transaminase activity
GO:0052656 L-isoleucine-2-oxoglutarate transaminase activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009081 branched-chain amino acid metabolic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009097 isoleucine biosynthetic process
GO:0009098 L-leucine biosynthetic process
GO:0009099 L-valine biosynthetic process
GO:0019752 carboxylic acid metabolic process
GO:0046394 carboxylic acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6thq, PDBe:6thq, PDBj:6thq
PDBsum6thq
PubMed
UniProtF2L0W0

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