Structure of PDB 6t65 Chain C

Receptor sequence
>6t65C (length=218) Species: 470 (Acinetobacter baumannii) [Search protein sequence]
QERKVALVTGASRGIGAAIAQQLIQDGYFVVGTATSESGAQKLTDSFGEQ
GAGLALDVRNLDEIEAVVSHIEQNYGPVLVLVNNALLRMSEDDWDDILNI
HLKAVYRLSKRVLKGMTKARFGRIINISSVVAHNYSAAKAGIEAFSRSLA
KEMGSRQITVNSVAPGFIATEMKKMSDQVALNRLGEPQDIANAVSFLASD
KAGYITGTVLHVNGGLYM
3D structure
PDB6t65 A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens.
ChainC
Resolution2.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G16 S138 Y151
Catalytic site (residue number reindexed from 1) G14 S129 Y135
Enzyme Commision number 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MLH C L107 L111 K112 A153 G157 L98 L102 K103 A137 G141
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0051287 NAD binding
Biological Process
GO:0006633 fatty acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6t65, PDBe:6t65, PDBj:6t65
PDBsum6t65
PubMed33388594
UniProtV5VHN7

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