Structure of PDB 6sof Chain C

Receptor sequence
>6sofC (length=719) Species: 9606 (Homo sapiens) [Search protein sequence]
HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHG
CTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQD
WRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLL
CTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNL
AAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSF
YALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKG
RQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDL
LGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPG
WLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLD
PISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKG
LKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESS
FRKTFEDYLHNVVFVPRPS
3D structure
PDB6sof Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain.
ChainC
Resolution4.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C R498 N711 F714 S719 R498 N711 F714 S719
BS02 peptide C D535 P537 N547 G550 W551 D535 P537 N547 G550 W551
External links
PDB RCSB:6sof, PDBe:6sof, PDBj:6sof
PDBsum6sof
PubMed31727777
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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