Structure of PDB 6slo Chain C

Receptor sequence
>6sloC (length=209) Species: 1439318 (Citrobacter freundii MGH 56) [Search protein sequence]
IIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPILDEIADEYQGKL
TVAKLNIDQNPGTAPKYGIRGIPTLLLFKNGEVAATKVGALSKGQLKEFL
DANLAGSAMESTVMVLRNMVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQ
EKQGEEEDAEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVYDQE
RFDNSDLSA
3D structure
PDB6slo Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly.
ChainC
Resolution1.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LJT C M466 E479 E483 K486 F487 L529 R532 F534 V539 M119 E132 E136 K139 F140 L182 R185 F187 V192 MOAD: ic50=178.1uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0015035 protein-disulfide reductase activity

View graph for
Molecular Function
External links
PDB RCSB:6slo, PDBe:6slo, PDBj:6slo
PDBsum6slo
PubMed33159082
UniProtQ9UHX1|PUF60_HUMAN Poly(U)-binding-splicing factor PUF60 (Gene Name=PUF60)

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