Structure of PDB 6rne Chain C

Receptor sequence
>6rneC (length=68) Species: 9606 (Homo sapiens) [Search protein sequence]
PFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGT
DECAIESIAVAATPIPKL
3D structure
PDB6rne DPP1 Inhibitors: Exploring the Role of Water in the S2 Pocket of DPP1 with Substituted Pyrrolidines.
ChainC
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H381 N403
Catalytic site (residue number reindexed from 1) H10 N32
Enzyme Commision number 3.4.14.1: dipeptidyl-peptidase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KA8 C N380 H381 N9 H10 PDBbind-CN: -logKd/Ki=8.80,IC50=1.58nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6rne, PDBe:6rne, PDBj:6rne
PDBsum6rne
PubMed31413809
UniProtP53634|CATC_HUMAN Dipeptidyl peptidase 1 (Gene Name=CTSC)

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