Structure of PDB 6rjg Chain C

Receptor sequence

>6rjgC (length=814) Species: 1268061 (Streptococcus thermophilus DGCC 7710) [Search protein sequence]

DLVLGLDIGIGSVGVGILNKVTGEIIHKNSRIFPAAQAENNLVRRTNRQG
RRLTRRKKHRRVRLNRLFEESGLITDFTKISINLNPYQLRVKGLTDELSN
EELFIALKNMVKHRGISYLGDYAQIVKENSKQLETKTPGQIQLERYQTYG
QLRGDFTVEKDGKKHRLINVFPTSAYRSEALRILQTQQEFNPQITDEFIN
RYLEILTGKRKYYHGPGNEKSRTDYGRYRTSGETLDNIFGILIGKCTFYP
DEFRAAKASYTAQEFNLLNDLNNLLSKEQKNQIINYVKNEKAMGPAKLFK
YIAKLLSCDVADIKGYRIDKSGKAEIHTFEAYRKMKTLETLDIEQMDRET
LDKLAYVLTLNTEREGIQEALEHEFADGSFSQKQVDELVQFRKANSSIFG
KGWHNFSVKLMMELIPELYETSEEQMTILTRLGKQKTTSSSNKTKYIDEK
LLTEEIYNPVVAKSVRQAIKIVNAAIKEYGDFDNIVIEASRVVLNALQEH
FRAHKIDTKVSVVEDSILFSYQVDSKFNRKISDATIYATRQAKVGKDKAD
ETYVLGKIKDIYTQDGYDAFMKIYKKDKSKFLMYRHDPQTFEKVIEPILE
NPFLKYKEEHGYIRKYSKKGNGPEIKSLKYYDSKLGNHIDITPKDSNNKV
VLQSVSPWRADVYFNKTTGKYEILGLKYADLQFEKGTGTYKISQEKYNDI
KKKEGVDSDSEFKFTLYKNDLLLVKDTETKEQQLFRFLSRTMPKQKHYVE
LKPYDKQKFEGGEALIKVLGNVANSGQCKKGLGKSNISIYKVRTDVLGNQ
HIIKNEGDKPKLDF

3D structure

PDB

6rjg Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6.

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	C	R46 R47 N49 Q51 R53 R54 L55 R57 R58 K60 H61 R63 I84 N85 Y89 K110 H115 R116 G117 L165 R166 G167 R223 Y225 P229 G230 N231 K233 S234 Y238 T260 K270 N279 R338 E346 H348 H425 N426 F427 Q446 M447 K464 T465 K466 K484 K491 V814 K817 N819 R820 K821 I822 I827 A829 M874 H877 K922 S924 P930 E931 K933 S934 N954 V957 F990 K992 Y997 R1100 D1102 H1108	R44 R45 N47 Q49 R51 R52 L53 R55 R56 K58 H59 R61 I82 N83 Y87 K108 H113 R114 G115 L152 R153 G154 R210 Y212 P216 G217 N218 K220 S221 Y225 T247 K257 N266 R317 E325 H327 H404 N405 F406 Q425 M426 K443 T444 K445 K463 K470 V523 K526 N528 R529 K530 I531 I536 A538 M583 H586 K615 S617 P623 E624 K626 S627 N647 V650 F683 K685 Y690 R793 D795 H801
BS02	dna	C	Y225 F252 G257 G336 E445 M447 D824 T826 Q1052 Y1055 N1081 S1082	Y212 F239 G244 G315 E424 M426 D533 T535 Q745 Y748 N774 S775
BS03	dna	C	S940 K941 G943 N944 V962 S1046 M1049 Q1084	S633 K634 G636 N637 V655 S739 M742 Q777

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0004519	endonuclease activity
GO:0046872	metal ion binding

	Biological Process
GO:0043571	maintenance of CRISPR repeat elements
GO:0051607	defense response to virus

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6rjg, PDBe:6rjg, PDBj:6rjg
PDBsum	6rjg
PubMed	31604602
UniProt	Q03LF7\|CAS9A_STRTD CRISPR-associated endonuclease Cas9 1 (Gene Name=cas9-1)

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