Structure of PDB 6rja Chain C

Receptor sequence

>6rjaC (length=815) Species: 322159 (Streptococcus thermophilus LMD-9) [Search protein sequence]

DLVLGLDIGIGSVGVGILNKVTGEIIHKNSRIFPAAQAENNLVRRTNRQG
RRLTRRKKHRRVRLNRLFEESGLITDFTKISINLNPYQLRVKGLTDELSN
EELFIALKNMVKHRGISYLDGDYAQIVKENSKQLETKTPGQIQLERYQTY
GQLRGDFTVEKDGKKHRLINVFPTSAYRSEALRILQTQQEFNPQITDEFI
NRYLEILTGKRKYYHGPGNEKSRTDYGRYRTSGETLDNIFGILIGKCTFY
PDEFRAAKASYTAQEFNLLNDLNNSKEQKNQIINYVKNEKAMGPAKLFKY
IAKLLSCDVADIKGYRIDKSGKAEIHTFEAYRKMKTLETLDIEQMDRETL
DKLAYVLTLNTEREGIQEALEHEFADGSFSQKQVDELVQFRKANSSIFGK
GWHNFSVKLMMELIPELYETSEEQMTILTRLGKTKYIDEKLLTEEIYNPV
VAKSVRQAIKIVNAAIKEYGDFDNIVIESRVVLNALQEHFRAHKIDTKVS
VHHHAVDALIIAASSDSILFSYQVDSKFNRKISDATIYATRQAKVGKDKA
DETYVLGKIKDIYTQDGYDAFMKIYKKDKSKFLMYRHDPQTFEKVIEPIL
ENPFLKYKEEHGYIRKYSKKGNGPEIKSLKYYDSKLGNHIDITPKDSNNK
VVLQSVSPWRADVYFNKTTGKYEILGLKYADLQFEKGTGTYKISQEKYND
IKKKEGVDSDSEFKFTLYKNDLLLVKDTETKEQQLFRFLSRTMPKQKHYV
ELKPYDKQKFEGGEALIKVLGNVANSGQCKKGLGKSNISIYKVRTDVLGN
QHIIKNEGDKPKLDF

3D structure

PDB

6rja Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6.

Chain

Resolution

3.0 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	C	N42 N43 R46 R47 N49 R50 Q51 R53 R54 R57 R58 H61 R63 R68 I84 N85 P88 Y89 K110 K114 R116 G117 L165 R166 G167 K222 R223 Y225 P229 G230 N231 K233 S234 T236 T260 R338 H348 K422 N426 M447 K464 T465 Y467 R487 R692 K817 N819 R820 K821 I822 I827 K850 L873 M874 H877 K922 S924 K925 P930 E931 K933 S934 K936 D952 N954 F990 E991 K992 Y997 R1100 T1101 H1108	N40 N41 R44 R45 N47 R48 Q49 R51 R52 R55 R56 H59 R61 R66 I82 N83 P86 Y87 K108 K112 R114 G115 L153 R154 G155 K210 R211 Y213 P217 G218 N219 K221 S222 T224 T248 R316 H326 K400 N404 M425 K433 T434 Y436 R456 R480 K527 N529 R530 K531 I532 I537 K560 L583 M584 H587 K616 S618 K619 P624 E625 K627 S628 K630 D646 N648 F684 E685 K686 Y691 R794 T795 H802
BS02	dna	C	Y120 Y225 F252 R267 N286 K335 E445 M447 Y478	Y118 Y213 F240 R255 N274 K313 E423 M425 Y447

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0004519	endonuclease activity
GO:0046872	metal ion binding

	Biological Process
GO:0043571	maintenance of CRISPR repeat elements
GO:0051607	defense response to virus

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6rja, PDBe:6rja, PDBj:6rja
PDBsum	6rja
PubMed	31604602
UniProt	Q03LF7\|CAS9A_STRTD CRISPR-associated endonuclease Cas9 1 (Gene Name=cas9-1)

[Back to BioLiP]