Structure of PDB 6r8y Chain C

Receptor sequence
>6r8yC (length=117) Species: 9606 (Homo sapiens) [Search protein sequence]
KARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYL
TAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVL
PNIQAVLLPKKTESHHK
3D structure
PDB6r8y DNA damage detection in nucleosomes involves DNA register shifting.
ChainC
Resolution4.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C A15 R18 R21 R30 R43 H124 A6 R9 R12 R21 R34 H115
BS02 dna C R12 R30 R43 V44 G45 K76 T77 R78 R3 R21 R34 V35 G36 K67 T68 R69
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
GO:0061644 protein localization to CENP-A containing chromatin
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0043505 CENP-A containing nucleosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6r8y, PDBe:6r8y, PDBj:6r8y
PDBsum6r8y
PubMed31142837
UniProtP04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)

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