Structure of PDB 6r8g Chain C

Receptor sequence
>6r8gC (length=312) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
TKIALIGSGQIGAIVGELCLLENLGDLILYDVVPGIPQGKALDLKHFSTI
LGVNRNILGTNQIEDIKDADIIVITAGVQRKEGMTREDLIGVNGKIMKSV
AESVKLHCSKAFVICVSNPLDIMVNVFHKFSNLPHEKICGMAGILDTSRY
CSLIADKLKVSAEDVNAVILGGHGDLMVPLQRYTSVNGVPLSEFVKKNMI
SQNEIQEIIQKTRNMGAEIIKLAKASAAFAPAAAITKMIKSYLYNENNLF
TCAVYLNGHYNCSNLFVGSTAKINNKGAHPVEFPLTKEEQDLYTESIASV
QSNTQKAFDLIK
3D structure
PDB6r8g Oligomeric interfaces as a tool in drug discovery: Specific interference with activity of malate dehydrogenase of Plasmodium falciparum in vitro.
ChainC
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.27: L-lactate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JUT C V161 N188 V160 N187
BS02 NAD C G10 Q11 I12 D32 V33 T76 A77 G78 I97 V117 N119 M142 H174 G9 Q10 I11 D31 V32 T75 A76 G77 I96 V116 N118 M141 H173 MOAD: Kd=172uM
BS03 JUT C L250 T271 A272 K273 V282 F284 L249 T270 A271 K272 V281 F283
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0019752 carboxylic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6r8g, PDBe:6r8g, PDBj:6r8g
PDBsum6r8g
PubMed
UniProtQ6VVP7

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