Structure of PDB 6qzw Chain C

Receptor sequence
>6qzwC (length=833) Species: 9606 (Homo sapiens) [Search protein sequence]
LEPFYVERYSWSQLKKLLADTRKYHKAPHDFMFVKRNDPDGPHSDRIYYL
AMSRENTLFYSEIPKTINRAAVLMLSWKPLLDLYSREEELLRERKRIGTV
GIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNI
RMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDAR
SAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEII
HVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKEL
IQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIP
VEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEI
EFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAI
TSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVT
RLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTK
EFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPT
VLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKF
EGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMA
LMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQ
AEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQER
HSIRVPESGEHYELHLLHYLQENLGSRIAALKV
3D structure
PDB6qzw Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair
ChainC
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Y669 S755 Y756 D833 H865
Catalytic site (residue number reindexed from 1) Y605 S691 Y692 D769 H801
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide C E275 E276 Y669 S755 Y756 Y787 Y791 N835 E211 E212 Y605 S691 Y692 Y723 Y727 N771
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0043069 negative regulation of programmed cell death
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6qzw, PDBe:6qzw, PDBj:6qzw
PDBsum6qzw
PubMed
UniProtQ6V1X1|DPP8_HUMAN Dipeptidyl peptidase 8 (Gene Name=DPP8)

[Back to BioLiP]