Structure of PDB 6qzv Chain C

Receptor sequence
>6qzvC (length=808) Species: 9606 (Homo sapiens) [Search protein sequence]
PAARFQVQKHSWDGLRSIIHGSRKAPHDFQFVQKTDESGPHSHRLYYLGM
PRENSLLYSEIPKKLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGV
FGITSYDFHSESGLFLFQASNSLFHCRDGNGFMVSPMKPLEIKTQCSGPR
MDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQVLDDPKSAGVA
TFVIQEEFDRFTGYWWCPTASWLKTLRILYEEVDESEVEVIHVPSPALEE
RKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFP
KVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRL
ASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSDELCFLRANECKTG
FCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARH
GSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSC
SMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEADY
VPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNS
FKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQ
VEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAP
VTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHG
FLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTL
LHFLQEYL
3D structure
PDB6qzv Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair
ChainC
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Y644 S730 Y731 D808 H840
Catalytic site (residue number reindexed from 1) Y589 S675 Y676 D753 H785
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C R133 E249 Q648 Y762 Y766 N810 H840 R97 E207 Q593 Y707 Y711 N755 H785
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis
GO:0043069 negative regulation of programmed cell death
GO:0070269 pyroptotic inflammatory response
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005874 microtubule
GO:0031252 cell leading edge

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6qzv, PDBe:6qzv, PDBj:6qzv
PDBsum6qzv
PubMed
UniProtQ86TI2|DPP9_HUMAN Dipeptidyl peptidase 9 (Gene Name=DPP9)

[Back to BioLiP]