Structure of PDB 6qs4 Chain C

Receptor sequence

>6qs4C (length=630) Species: 566546 (Escherichia coli W)

QALKKYTIDLTERAEQGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEP
GVGKTAIVEGLAQRIINGEVPEGLKGRRVLALDMGALVAGAKYRGEFEER
LKGVLNDLAKQEGNVILFIDALHTMVGAGKADGAMDAGNMLKPALARGEL
HCVGATTLDEYRQYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKERYE
LHHHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEAASSIRMQIDSK
PEELDRLDRRIIQLKLEQQALMLDMLNEELSDKERQYSELEEEWKAEKLR
NKVTDAEIAEVLARWTGIPVSRMMESEREKLLRMEQELHHRVIGQNEAVD
AVSNAIRRSRAGLADPNRPIGSFLFLGPTGVGKTELCKALANFMFDSDEA
MVRIDMSEFMEKHSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDA
VEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNLGSDLIQER
FGELDYAHMKELVLGVVSHNFRPEFINRIDEVVVFHPLGEQHIASIAQIQ
LKRLYKRLEERGYEIHISDEALKLLSENGYDPVYGARPLKRAIQQQIENP
LAQQILSGELVPGKVIRLEVNEDRIVAVQH

3D structure

• PDB: 6qs4 Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor.
• Chain: C
• Resolution: 4.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	K250 Y251 R252 G652 Y653	K92 Y93 R94 G424 Y425
BS02	AGS	C	V180 I181 G209 V210 G211 K212 T213 A214 I349 P387 I391	V22 I23 G51 V52 G53 K54 T55 A56 I191 P229 I233
BS03	AGS	C	R331 R332	R173 R174
BS04	AGS	C	R569 I571 T607 G608 V609 G610 K611 T612 E613 I774 R815 K818	R341 I343 T379 G380 V381 G382 K383 T384 E385 I546 R587 K590

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0009408 response to heat
• GO:0034605 cellular response to heat
• GO:0042026 protein refolding

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6qs4, PDBe:6qs4, PDBj:6qs4
• PDBsum: 6qs4
• PubMed: 31216466
• UniProt: E0J719