Structure of PDB 6qje Chain C

Receptor sequence
>6qjeC (length=384) Species: 9606 (Homo sapiens) [Search protein sequence]
ALRQPQVAELLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLV
LPMALELMTVLVGSPRLVSLLTTSEGADEPQRLQFPLPTAQRSLEPGTPR
WANYVKGVIQYYPAAPLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQ
LCPDSGTIAARAQVCQQAEHSFAGMPCGIMDQFISLMGQKGHALLIDCRS
LETSLVPLSDPKLAVLITNSNVRHSSEYPVRRRQCEEVARALGAASLREV
QLEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDYRAFGRLMV
ESHRSLRDDYEVSCPELDQLVEAALAVPGVYGSRMTGGGFGGCTVTLLEA
SAAPHAMRHIQEHYGGTATFYLSQAADGAKVLCL
3D structure
PDB6qje Structure of human galactokinase 1 bound with 4-{[2-(Methylsulfonyl)-1H-imidazol-1-yl]methyl}-1,3-thiazole
ChainC
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.6: galactokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL C E43 H44 D46 G183 M185 D186 G346 E41 H42 D44 G178 M180 D181 G338
BS02 HFK C Y109 V129 L135 S141 S142 L145 Y104 V124 L130 S136 S137 L140
Gene Ontology
Molecular Function
GO:0004335 galactokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005534 galactose binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0006012 galactose metabolic process
GO:0016310 phosphorylation
GO:0019402 galactitol metabolic process
GO:0033499 galactose catabolic process via UDP-galactose
GO:0046835 carbohydrate phosphorylation
GO:0061623 glycolytic process from galactose
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qje, PDBe:6qje, PDBj:6qje
PDBsum6qje
PubMed
UniProtP51570|GALK1_HUMAN Galactokinase (Gene Name=GALK1)

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