Structure of PDB 6qau Chain C

Receptor sequence
>6qauC (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
GSMEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKILLGK
EIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSE
DTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIK
IADFGFARYLHSSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPF
QFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQ
3D structure
PDB6qau Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).
ChainC
Resolution2.48 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D131 K133 Q135 N136 D158 S177
Catalytic site (residue number reindexed from 1) D126 K128 Q130 N131 D153 S163
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1FV C H17 V23 A37 M85 E86 Y87 C88 N89 G91 L138 D158 H19 V25 A39 M80 E81 Y82 C83 N84 G86 L133 D153 BindingDB: IC50=38nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0010506 regulation of autophagy

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Molecular Function
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Biological Process
External links
PDB RCSB:6qau, PDBe:6qau, PDBj:6qau
PDBsum6qau
PubMed30782972
UniProtQ8IYT8|ULK2_HUMAN Serine/threonine-protein kinase ULK2 (Gene Name=ULK2)

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