Structure of PDB 6q8z Chain C

Receptor sequence

>6q8zC (length=386) Species: 9606 (Homo sapiens)

ALRQPQVAELLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLV
LPMALELMTVLVGSPRLVSLLTTSEGADEPQRLQFPLPTAQRSLEPGTPR
WANYVKGVIQYYPAAPLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQ
LCPDSGTIAARAQVCQQAEHSFAGMPCGIMDQFISLMGQKGHALLIDCRS
LETSLVPLSDPKLAVLITNSNVRHSLASEYPVRRRQCEEVARALGKESLR
EVQLEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDYRAFGRL
MVESHRSLRDDYEVSCPELDQLVEAALAVPGVYGSRMTGGGFGGCTVTLL
EASAAPHAMRHIQEHYGGTATFYLSQAADGAKVLCL

3D structure

• PDB: 6q8z Structure of human galactokinase 1 bound with N-(Cyclobutylmethyl)-1,5-dimethyl-1H-pyrazole-4-carboxamide
• Chain: C
• Resolution: 2.4 Å

Enzymatic activity

• Enzyme Commision number: 2.7.1.6: galactokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GAL	C	E43 H44 D46 Y47 G183 D186 Y236 G346	E41 H42 D44 Y45 G178 D181 Y230 G340
BS02	HFK	C	W106 Y109 V129 S131 G136 S141 S142 L145 R228	W101 Y104 V124 S126 G131 S136 S137 L140 R223
BS03	HR5	C	V9 L13 A31 V32 S33 V62 K388	V7 L11 A29 V30 S31 V60 K382

Gene Ontology

Molecular Function

• GO:0004335 galactokinase activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0005534 galactose binding
• GO:0016301 kinase activity
• GO:0016773 phosphotransferase activity, alcohol group as acceptor

Biological Process

• GO:0006012 galactose metabolic process
• GO:0016310 phosphorylation
• GO:0019402 galactitol metabolic process
• GO:0033499 galactose catabolic process via UDP-galactose
• GO:0046835 carbohydrate phosphorylation
• GO:0061623 glycolytic process from galactose

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0016020 membrane
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:6q8z, PDBe:6q8z, PDBj:6q8z
• PDBsum: 6q8z
• UniProt: P51570|GALK1_HUMAN Galactokinase (Gene Name=GALK1)