Structure of PDB 6pzv Chain C

Receptor sequence
>6pzvC (length=226) Species: 9913 (Bos taurus) [Search protein sequence]
SPKCTECLQYLDDPELRYEQHPPDAVEEIQILTNERLSIFSYEDLPQHKL
TCFSVYCKRGHLCPIDTGLIEKDVELLFSGSAKPIYEDDPSPEGGINGKN
FGPINEWWIAGFDGGEKALLGFSTSFAEYILMDPSPEYAPLFSVMQEKIY
ISKIVVEFLQSNPDSTYEDLINKIETTVPPCMLNLNRFTEDSLLRHAQFV
VEQVESYDRAGFLSPCMRDLIKLAGV
3D structure
PDB6pzv Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation.
ChainC
Resolution3.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C I425 E426 D428 N460 E461 W462 W463 I464 E483 Q558 S561 Y562 A565 I70 E71 D73 N105 E106 W107 W108 I109 E128 Q203 S206 Y207 A210
BS02 ZN C C351 H416 C4 H61
External links
PDB RCSB:6pzv, PDBe:6pzv, PDBj:6pzv
PDBsum6pzv
PubMed32675241
UniProtQ24K09|DNMT1_BOVIN DNA (cytosine-5)-methyltransferase 1 (Gene Name=DNMT1)

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