Structure of PDB 6pza Chain C

Receptor sequence
>6pzaC (length=1422) Species: 10034 (Cricetus cricetus) [Search protein sequence]
MPLAFCGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIG
WGSQSSKVHIHHSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDGVTE
SRHLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITK
TIKFVKFYDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKT
PREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAI
AKLPIAMRALTNYQRLCVAFDAQARKDTQSPQGARAIWRALCHAFGRRLI
LSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQE
FLGNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIM
HMSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWTMPVQIIVGVI
LLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRTTLEHSNERLKQTN
EMLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAI
PIAAVLITFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRST
VKALVSVQKLSEFLSSAEIRECVQIIGGFFTWTPDGIPTLSNITIRIPRG
QLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSNRSRGPVAYASQKPW
LLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGI
NLSGGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILELLR
DDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHW
QRAKIPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSA
LVLDQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRII
LAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTV
ISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLVSHFAE
TVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVCMEYIG
ACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADME
IQLGAVKRIHALLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDS
SLKPVLKHVNTLISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIID
GIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALE
IAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMD
EATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGA
ILEFDKPETLLSQKDSVFASFV
3D structure
PDB6pza Mechanism of pharmacochaperoning in a mammalian K ATP channel revealed by cryo-EM.
ChainC
Resolution3.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C R826 S1120 W1297 R748 S964 W1141
BS02 GBM C R306 Y377 I381 F433 L434 N437 L592 L1241 T1242 R1246 R1300 R306 Y377 I381 F433 L434 N437 L592 L1085 T1086 R1090 R1144
BS03 ATP C W688 G716 C717 G718 K719 S720 Q775 W632 G660 C661 G662 K663 S664 Q697
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pza, PDBe:6pza, PDBj:6pza
PDBsum6pza
PubMed31343405
UniProtQ09427|ABCC8_CRICR ATP-binding cassette sub-family C member 8 (Gene Name=ABCC8)

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