Structure of PDB 6pz9 Chain C

Receptor sequence

>6pz9C (length=1177) Species: 10034 (Cricetus cricetus)

VNLLSKGTYWWMNAFIKTAHKKPIDLRAIAKLPIAMRALTNYQRLCVAFD
AQARKDTQSPQGARAIWRALCHAFGRRLILSSTFRILADLLGFAGPLCIF
GIVDHLGKEVSSQEFLGNAYVLAVLLFLALLLQRTFLQASYYVAIETGIN
LRGAIQTKIYNKIMHMSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCP
NLWTMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQR
TTLEHSNERLKQTNEMLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAF
AVYTSISIFMNTAIPIAAVLITFVGHVSFFKESDLSPSVAFASLSLFHIL
VTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIRECVQIIGGFFTWTPDG
IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSN
RSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDI
LPHGDQTQIGERGINLSGGQRQRISVARALYQQTNVVFLDDPFSALDVHL
SDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTL
KDFQRSECQLFEHWQRAKIPWRACTKYLSSAGILLLSLLVFSQLLKHMVL
VAIDYWLAKWTDSADQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAK
RLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSR
STLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDT
TQLPLVSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAAN
RWLEVCMEYIGACVVLIAAATSISNSLHLVGLGLTYALMVSNYLNWMVRN
LADMEIQLGAVKRIHALLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLS
VRYDSSLKPVLKHVNTLISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEG
RIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTL
WEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTS
IFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMV
LKRGAILEFDKPETLLSQKDSVFASFV

3D structure

• PDB: 6pz9 Mechanism of pharmacochaperoning in a mammalian K ATP channel revealed by cryo-EM.
• Chain: C
• Resolution: 3.65 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	W430 L592 R826 P1117 N1123 C1142 R1145 S1146 Y1294 W1297 N1301	W194 L356 R512 P722 N728 C747 R750 S751 Y893 W896 N900
BS02	BJX	C	Y377 I381 W430 F433 L434 N437 L592 R1246 W1297 R1300	Y141 I145 W194 F197 L198 N201 L356 R851 W896 R899
BS03	ATP	C	S405 N406 W688 V715 G716 C717 G718 K719 S720 S721 Q775	S169 N170 W396 V423 G424 C425 G426 K427 S428 S429 Q461

Gene Ontology

Molecular Function

• GO:0005267 potassium channel activity
• GO:0005524 ATP binding
• GO:0008281 sulfonylurea receptor activity
• GO:0016887 ATP hydrolysis activity
• GO:0042626 ATPase-coupled transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0006813 potassium ion transport
• GO:0055085 transmembrane transport
• GO:0071805 potassium ion transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:6pz9, PDBe:6pz9, PDBj:6pz9
• PDBsum: 6pz9
• PubMed: 31343405
• UniProt: Q09427|ABCC8_CRICR ATP-binding cassette sub-family C member 8 (Gene Name=ABCC8)