Structure of PDB 6py8 Chain C

Receptor sequence

>6py8C (length=429) Species: 9606 (Homo sapiens)

RPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVY
LMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCT
AKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSL
KNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHL
LDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALL
DADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMIND
GASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELT
GQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQV
PVTLVRNDGIIYSTSLTFTYTPEPGPRPH

3D structure

• PDB: 6py8 Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling.
• Chain: C
• Resolution: 3.75 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	C	K50 R51 F52 K152 R178 S181 K271	K40 R41 F42 K142 R168 S171 K261
BS02	dna	C	K44 Y46 S151 K152 S154 K156 K157 R180 Q182	K34 Y36 S141 K142 S144 K146 K147 R170 Q172

Gene Ontology

Molecular Function

• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006357 regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:6py8, PDBe:6py8, PDBj:6py8
• PDBsum: 6py8
• PubMed: 31690634
• UniProt: Q06330|SUH_HUMAN Recombining binding protein suppressor of hairless (Gene Name=RBPJ)