Structure of PDB 6pqp Chain C

Receptor sequence

>6pqpC (length=615) Species: 9606 (Homo sapiens) [Search protein sequence]

KKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHD
KVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLD
EDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEV
VLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHS
TEDKSCRDYYIEYNFKYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRI
ELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMA
FNSTGIINILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKRNYFMD
ISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQR
FENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSPL
LSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVL
MNLLIGLAVGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKS
TIVYPNKPRSGGMLFHIFCFLFCTSLEMEILKQKYRLKDLTFLLEKQHEL
IKLIIQKMEIISETE

3D structure

PDB

6pqp Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.

Chain

Resolution

3.06 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	6OU	C	P934 V935	P482 V483
BS02	6OU	C	S900 L902 L903	S448 L450 L451
BS03	6OU	C	I878 L882 L902	I426 L430 L450
BS04	9BE	C	F612 C621 P622 I623 K661 Y662 Q664	F167 C176 P177 I178 K216 Y217 Q219
BS05	6OU	C	K868 L871	K416 L419
BS06	6OU	C	T813 Q833	T361 Q381
BS07	6OU	C	Y926 F938 V942 I946	Y474 F486 V490 I494
BS08	LBN	C	I803 M844 I860 E864 K868 L871	I351 M392 I408 E412 K416 L419

Gene Ontology

	Molecular Function
GO:0005216	monoatomic ion channel activity
GO:0005262	calcium channel activity
GO:0015267	channel activity
GO:0015278	intracellularly gated calcium channel activity
GO:0042802	identical protein binding
GO:0097604	temperature-gated cation channel activity

	Biological Process
GO:0006811	monoatomic ion transport
GO:0006816	calcium ion transport
GO:0006874	intracellular calcium ion homeostasis
GO:0007166	cell surface receptor signaling pathway
GO:0009409	response to cold
GO:0009410	response to xenobiotic stimulus
GO:0014070	response to organic cyclic compound
GO:0019233	sensory perception of pain
GO:0019722	calcium-mediated signaling
GO:0042542	response to hydrogen peroxide
GO:0048265	response to pain
GO:0050955	thermoception
GO:0050966	detection of mechanical stimulus involved in sensory perception of pain
GO:0050968	detection of chemical stimulus involved in sensory perception of pain
GO:0050974	detection of mechanical stimulus involved in sensory perception
GO:0051289	protein homotetramerization
GO:0055085	transmembrane transport
GO:0070301	cellular response to hydrogen peroxide
GO:0070588	calcium ion transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0032421	stereocilium bundle

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6pqp, PDBe:6pqp, PDBj:6pqp
PDBsum	6pqp
PubMed	31866091
UniProt	O75762\|TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1 (Gene Name=TRPA1)

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