Structure of PDB 6pmp Chain C

Receptor sequence
>6pmpC (length=617) Species: 10116 (Rattus norvegicus) [Search protein sequence]
FGVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPNISMCHQGLLSFEGFA
RFLMDKDNFASKNDESRENKKDLQLPLSYYYIESSHNTYLTGHQLKGESS
VELYSQVLLQGCRSIELDCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDR
SAFITSDLPIIISIENHCSLPQQRKMAEIFKSVFGEKLVAKFLFETDFSP
MLPSPDQLRRKVLLKNKKLKAHQTPVDILKQKAHQLASMKVYDMELGEEF
YLPQNKKESRQIAPELSDLVIYCQAVKFPGLRTPKCYHISSLNENAAKRL
CRRYSQKLIQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVALNYQT
DDLPLHLNAAMFEANGGCGYVLKPPVLWDKSCPMYQKFSPLERDLDAMDP
ATYSLTIISGQNVCPSNSTGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNP
MWNEQFLFRVHFEDLVFLRFAVVENNSSAITAQRIIPLKALKRGYRHLQL
RNLHNEILEISSLFINSRRMEDRPASLMFNTEERKCSQTHKVTVHGVPGP
EPFAVFTINEGTKAKQLLQQILADYFLMEEKHFIPFQRAVGPEEDIVQIL
NSWFPEEGYVGRIVLKP
3D structure
PDB6pmp Structure of phospholipase C epsilon reveals an integrated RA1 domain and previously unidentified regulatory elements.
ChainC
Resolution2.73 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H1388 N1389 E1418 D1420 H1433 E1467
Catalytic site (residue number reindexed from 1) H86 N87 E116 D118 H131 E165
Enzyme Commision number 3.1.4.11: phosphoinositide phospholipase C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C N1389 E1418 D1420 E1467 N87 E116 D118 E165
Gene Ontology
Molecular Function
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6pmp, PDBe:6pmp, PDBj:6pmp
PDBsum6pmp
PubMed32796910
UniProtQ99P84|PLCE1_RAT 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (Gene Name=Plce1)

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