Structure of PDB 6pen Chain C

Receptor sequence
>6penC (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
NLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLR
APARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL
VRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGV
QSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLL
CKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNM
SASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKD
3D structure
PDB6pen Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation.
ChainC
Resolution4.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.1.1: microtubule-severing ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C K414 Y415 V416 H455 A457 K92 Y93 V94 H133 A135
BS02 ADP C D470 R498 D148 R176
BS03 BEF C R498 R499 R176 R177
BS04 ADP C A345 G385 N386 G387 K388 T389 M390 L517 G546 S547 A23 G63 N64 G65 K66 T67 M68 L195 G224 S225
BS05 BEF C P384 G385 K388 P62 G63 K66
BS06 MG C T389 D441 T67 D119
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008568 microtubule severing ATPase activity
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6pen, PDBe:6pen, PDBj:6pen
PDBsum6pen
PubMed31767681
UniProtQ9UBP0|SPAST_HUMAN Spastin (Gene Name=SPAST)

[Back to BioLiP]