Structure of PDB 6p4f Chain C

Receptor sequence

>6p4fC (length=436) Species: 273063 (Sulfurisphaera tokodaii str. 7)

GSVYLRYFKGLILSDAYAPGLKWSDELKAYSALAFKYRDVRKYFLEKEIE
VEENVIDSLPFPLIKDKIELRDYQAEAVKAWLKEKRGIIVLPTGAGKTQV
ALKIVSIMKVATLIVVPTIDLITQWKERINKYLDFDPGIIGGGEDSLKGI
TVITYDSAYTRAEELGNKFPLLIFDEVHHLPSEGYSIMAQLFASPYRLGL
TATPERDDGKHELYPILVGPIVYRKSVEELAGKYIAKYKIKKLYVSLTNE
EKKRYDGLRKKLKDFLSSRGLKLQNLDDFHRLVKLAAKDKEAREALLAWH
ESLNIAVNSQSKIEKLREILQEYKNEKIIVFTRDTQMAYRISKTFLIPVV
TYKTDKDEREEILQKFRDGEYRVIVASTVFDEGVDVPDATLAIVMGGYGT
KRQFLQRLGRILRKKDKEALLIEIVTKGTADYRLSR

3D structure

• PDB: 6p4f Structural basis of the XPB helicase-Bax1 nuclease complex interacting with the repair bubble DNA.
• Chain: C
• Resolution: 3.55 Å

Enzymatic activity

• Enzyme Commision number: 5.6.2.4: DNA 3'-5' helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	C	S181 E182 G183 Y184 R205 Q273 F278 W298 K355 Y397 G398 Q402	S182 E183 G184 Y185 R206 Q274 F279 W299 K356 Y398 G399 Q403
BS02	dna	C	T117 I118 G141 T153 S156 V282 K283 R292 L295 T334 Y351 S376 T377 V378	T118 I119 G142 T154 S157 V283 K284 R293 L296 T335 Y352 S377 T378 V379
BS03	MG	C	F330 F403	F331 F404
BS04	MG	C	D277 F278	D278 F279

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0004386 helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016853 isomerase activity
• GO:0140097 catalytic activity, acting on DNA

Biological Process

• GO:0006281 DNA repair
• GO:0071103 DNA conformation change

External links

• PDB: RCSB:6p4f, PDBe:6p4f, PDBj:6p4f
• PDBsum: 6p4f
• PubMed: 32986831
• UniProt: Q970I2|XPB2_SULTO DNA 3'-5' translocase XPB2 (Gene Name=xpb2)