Structure of PDB 6oqq Chain C

Receptor sequence

>6oqqC (length=743) Species: 446 (Legionella pneumophila)

KQYYFARRGETSTHDTSLPPPVKVLSGRSIPLKEIPFEATRNELVQIYLT
SIDKLIKSNKLNSIPSQQIASHYLFLRSLANSETDGIKKNQILSLAKPLG
TYLASKEPHVWKMINELIEKSEYPIIHYLKNNRAHSNFMLALIHEYHKEP
LTKNQSAFVQKFRDSSVFLFPNPIYTAWLAHSYDEDSSFNPMFRERLSTN
FYHSTLTDNLLLRTEPKEVTLSSEHHYKKEKGPIDSSFRYQMSSDRLLRI
QGRTLLFSTPQNDVVAVKVQKKGEPKSTLEEEFEMADYLLKHQRRLDVHS
KLPQPLGQYSVKKSEILEISRGSLDFERFKTLIDDSKDLEVYVYKAPQSY
FTYLHDKNQDLEDLTASVKTNVHDLFVLLREGIVFPQLADIFHTHFGEDE
REDKGRYQALVQLLNVLQFQLGRIDKWQKAVEYVNLRSSGLADLGDSLPI
TSLFTSSDFTKHYFSELLTGGYHPTFFDKSSGTANSLFTGKRRLFGNYLY
LNTIAEYLLVIQLTLGSYGDKVTRDMMDKPKKEAVWRELANVMFTSCAEA
IHIMTGIPQSRALTLLKQRANIEKHFRQTQFWMTPDYSKLDEDTLQMEQY
SIYSGEPEYEFTDKLVSGVGLSVDGVHQDLGGYNRESPLRELEKLLYATV
TLIEGTMQLDKEFFKQLEQVEKILSGEIKTDANSCFEAVAQLLDLARPGC
HFQKRLVLSYYEEAKLKYPSAPTDAYDSRFQVVARTNAAITIQ

3D structure

• PDB: 6oqq Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases.
• Chain: C
• Resolution: 2.102 Å

Enzymatic activity

• Enzyme Commision number: 6.-.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	AMP	C	H492 R500 D502 Y506 Q507 V510 Q517 Q519 G521	H393 R401 D403 Y407 Q408 V411 Q418 Q420 G422
BS02	POP	C	R352 K367 R536 D542	R253 K268 R437 D443
BS03	POP	C	T493 R500 Y732 N733	T394 R401 Y633 N634
BS04	MG	C	D542 D545	D443 D446

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0008234 cysteine-type peptidase activity
• GO:0016740 transferase activity
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:6oqq, PDBe:6oqq, PDBj:6oqq
• PDBsum: 6oqq
• PubMed: 31123136
• UniProt: Q5ZTK6|SIDJ_LEGPH Calmodulin-dependent glutamylase SidJ (Gene Name=sidJ)