Structure of PDB 6ooy Chain C

Receptor sequence
>6ooyC (length=134) Species: 9606 (Homo sapiens) [Search protein sequence]
KPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYS
QVLFKGQGCHVLLTHTISRIAVSYQTKVNLLSAIKSPCKPWYEPIYLGGV
FQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
3D structure
PDB6ooy Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.
ChainC
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A7M C Y59 S60 Y119 Y151 Y49 S50 Y96 Y128 MOAD: Kd=22uM
PDBbind-CN: -logKd/Ki=4.66,Kd=22uM
Gene Ontology
Molecular Function
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ooy, PDBe:6ooy, PDBj:6ooy
PDBsum6ooy
PubMed31857588
UniProtP01375|TNFA_HUMAN Tumor necrosis factor (Gene Name=TNF)

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