Structure of PDB 6oep Chain C

Receptor sequence
>6oepC (length=612) Species: 10090 (Mus musculus) [Search protein sequence]
HLLSLTRRAQKHRLRELKIQVKEFADKEEGGDVKAVCLTLFLLALRARNE
HRQADELEAIMQGRGSGLQPAVCLAIRVNTFLSCSQYHKMYRTVKAITGR
QIFQPLHALRNAEKVLLPGYHPFEWQPPLKNVSSRTDVGIIDGLSGLASS
VDEYPVDTIAKRFRYDSALVSALMDMEEDILEGMRSQDLDDYLNGPFTVV
VKESCDGMGDVSEKHGSGPAVPEKAVRFSFTVMRITIEHGSQNVKVFEEP
KPNSELCCKPLCLMLADESDHETLTAILSPLIAEREAMKSSELTLEMGGI
PRTFKFIFRGTGYDEKLVREVEGLEASGSVYICTLCDTTRLEASQNLVFH
SITRSHAENLQRYEVWRSNPYHESVEELRDRVKGVSAKPFIETVPSIDAL
HCDIGNAAEFYKIFQLEIGEVYKHPNASKEERKRWQATLDKHLRKRMNLK
PIMRMNGNFARKLMTQETVDAVCELIPSEERHEALRELMDLYLKMKPVWR
SSCPAKECPESLCQYSFNSQRFAELLSTKFKYRYEGKITNYFHKTLAHVP
EIIERDGSIGAWASNQSGNKLFRRFRKMNARQSKCYEMEDVLKHHWLYTS
KYLQKFMNAHNA
3D structure
PDB6oep Cutting antiparallel DNA strands in a single active site.
ChainC
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C L399 R402 A403 H406 H482 Y485 H501 S979 L5 R8 A9 H12 H88 Y91 H107 S583
BS02 dna C C478 N975 A976 R977 K989 C84 N579 A580 R581 K593
BS03 dna C G603 Q962 G209 Q566
BS04 dna C R440 N443 H445 I846 N850 N852 R46 N49 H51 I452 N456 N458
BS05 ZN C C727 H937 H942 C333 H543 H548
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0002250 adaptive immune response
GO:0002331 pre-B cell allelic exclusion
GO:0006310 DNA recombination
GO:0006325 chromatin organization
GO:0008542 visual learning
GO:0030183 B cell differentiation
GO:0033077 T cell differentiation in thymus
GO:0033151 V(D)J recombination
GO:0043029 T cell homeostasis
GO:0045580 regulation of T cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0048538 thymus development
GO:0051865 protein autoubiquitination
GO:0070233 negative regulation of T cell apoptotic process
GO:0070244 negative regulation of thymocyte apoptotic process
GO:2000822 regulation of behavioral fear response
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6oep, PDBe:6oep, PDBj:6oep
PDBsum6oep
PubMed32015552
UniProtP15919|RAG1_MOUSE V(D)J recombination-activating protein 1 (Gene Name=Rag1)

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