Structure of PDB 6oad Chain C

Receptor sequence

>6oadC (length=426) Species: 511145 (Escherichia coli str. K-12 substr. MG1655)

TEAMKITLSTQPADARWGEKATYSINNDGITLHLNGADDLGLIQRAARKI
DGLGIKHVQLSGEGWDADRCWAFWQGYKAPKGTRKVVWPDLDDAQRQELD
NRLMIIDWVRDTINAPAEELGPSQLAQRAVDLISNVAGDRVTYRITKGED
LREQGYMGLHTVGRGSERSPVLLALDYNPTGDKEAPVYACLVGKGITFDS
GGYSIKQTAFMDSMKSDMGGAATVTGALAFAITRGLNKRVKLFLCCADNL
ISGNAFKLGDIITYRNGKKVEVMNTDAEGRLVLADGLIDASAQKPEMIID
AATLTGAAKTALGNDYHALFSFDDALAGRLLASAAQENEPFWRLPLAEFH
RSQLPSNFAELNNTGSAAYPAGASTAAGFLSHFVENYQQGWLHIDCSATY
RKAPVEQWSAGATGLGVRTIANLLTA

3D structure

• PDB: 6oad Comparison of metal-bound and unbound structures of aminopeptidase B proteins from Escherichia coli and Yersinia pestis.
• Chain: C
• Resolution: 2.05 Å

Enzymatic activity

• Enzyme Commision number: 3.4.11.23: PepB aminopeptidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	C	K195 D200 D218 E279	K194 D199 D217 E278
BS02	ZN	C	D200 D277 E279	D199 D276 E278
BS03	CA	C	I114 A116 K216 M219	I113 A115 K215 M218
BS04	BCT	C	A278 G280 R281 L305	A277 G279 R280 L304

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0005515 protein binding
• GO:0008233 peptidase activity
• GO:0030145 manganese ion binding
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0019538 protein metabolic process
• GO:0043171 peptide catabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:6oad, PDBe:6oad, PDBj:6oad
• PDBsum: 6oad
• PubMed: 32306515
• UniProt: P37095|PEPB_ECOLI Peptidase B (Gene Name=pepB)