Structure of PDB 6o3v Chain C

Receptor sequence
>6o3vC (length=830) Species: 28875 (Rotavirus A) [Search protein sequence]
MKVLALRHSVAQVYADTQIYTHDDTKDSYENAFLISNLTTHNILYFNYSA
RTLEILNKSGIAAIEIQSLEELFTLIRCNFTYDYENNVVYLHDYSYYTNN
EIRTDQHWITKTNIEEYLLPGWKLTYVGYNGNDTRGHYNFSFTCQNAATD
DDIIIEYIYSEALDFQNFMLRKIKERMTTSLPIARLSNRVFRDKLFPLLV
KKHKRVVNVGPRNESMFTFLNFPSIRQFSNGPYLVKNTIKLKQERWLGKR
VSQFDIGQYKNMLNVITTIYHYYNLYQEKPIIYMVGSAPSYWIYDVRQYS
DFLFETWDPLDTPYSSIHHKELFFAKDIGKLKDNSILYIDIRTDRGNADW
KEWRKVVELQTISNLNLAYQYLATGKSKVCCVKLTAMDLELPVSAKLLHH
PTTEIRSEFYLLLDIWDVNNIKRFIPKGALYSFINNVITDNVFIQSPFKI
RTSVSDYIVALYALSNDFNNREDIINLINNQKQSLITVRINNTFKDEPKV
GFKSIYDWTFLPTDFETTNAIVTSYDGCLGIFGLSISLASKPTGNNHLFI
LNGTDKYYKLDQFANHTGISRRSHQVRFSESATSYSGYIFRDLSNSNFNL
IGTNVENSVSGHVYNALIYYRYNYSFDLKRWIYLHSVEKGKYYEHAPIEL
IYACKSAKEFASLQDDLTVLRYANEIENYINKVYSITYADDPNYFIGIKF
NNIPYIYDVKVPHLTFGVLYISDNMIPDVVKIMKSMKQELFGMDVTTSYT
YMLSDGVYVANVSGVLATYFKMYNLFYKNQITFGQSRMFIPHITLSFSNN
KTVRIETTKLRIKSIYLRKIRGDTVFDMPE
3D structure
PDB6o3v 2.7 angstrom cryo-EM structure of rotavirus core protein VP3, a unique capping machine with a helicase activity.
ChainC
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.7.7.50: mRNA guanylyltransferase.
3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GP C S573 H574 R577 Y588 G611 H612 N615 S573 H574 R577 Y588 G611 H612 N615
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004484 mRNA guanylyltransferase activity
GO:0005525 GTP binding
GO:0008168 methyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
GO:0016032 viral process
GO:0019049 virus-mediated perturbation of host defense response
GO:0032259 methylation
GO:0052170 symbiont-mediated suppression of host innate immune response
GO:0106005 RNA 5'-cap (guanine-N7)-methylation
Cellular Component
GO:0019013 viral nucleocapsid
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6o3v, PDBe:6o3v, PDBj:6o3v
PDBsum6o3v
PubMed32494598
UniProtQ1WK45

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