Structure of PDB 6muu Chain C

Receptor sequence

>6muuC (length=276) Species: 342948 (Thermococcus onnurineus) [Search protein sequence]

RFYGKIVIKGKIKAVTGLHIGSQIDNPVIKDPHTGLPYIPGSSLKGRLRS
LFEILVNSRLGEWREKYPSLANYSPGSCRPDNQENCGKFFNRKINRGWIH
VCPDYETALACPVCRLFGASGKESNFPSRIIVRDAFLTKEWEEKWRAGEA
ITEAKIEVGIDRVTSQANPRTNERVVAGAEFEFEIIYNVENTTHWRDDIK
NLLTAMALLEDSYLGGSGSRGYGKVKFIFDSFEFRPLDYYRTGKDEDIVS
IDAREKSVSDILSGFDSLFSEVEGKL

3D structure

PDB

6muu Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.

Chain

Resolution

3.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	C	I23 G24 S53 S54 K56 G57 R58 R60 S61 I105 G129 S131 N136 S139 E168 V169 I171 R173 S176 A178 R181 Y224 G226 G227 R231	I20 G21 S42 S43 K45 G46 R47 R49 S50 I94 G118 S120 N125 S128 E157 V158 I160 R162 S165 A167 R170 Y213 G215 G216 R220
BS02	ZN	C	H111 C122 C125	H100 C111 C114

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0004519	endonuclease activity

	Biological Process
GO:0051607	defense response to virus

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Molecular Function

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Biological Process

External links

PDB	RCSB:6muu, PDBe:6muu, PDBj:6muu
PDBsum	6muu
PubMed	30503773
UniProt	B6YWC0

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