Structure of PDB 6mta Chain C

Receptor sequence
>6mtaC (length=150) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDSYRKQVVIDGETCLLDILDT
DQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKC
DLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKE
3D structure
PDB6mta GTP hydrolysis is modulated by Arg34 in the RASopathy-associated KRASP34R.
ChainC
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP C G13 V14 G15 K16 S17 A18 F28 V29 N116 K117 D119 S145 G13 V14 G15 K16 S17 A18 F28 V29 N98 K99 D101 S127
BS02 MG C S17 D57 S17 D49
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6mta, PDBe:6mta, PDBj:6mta
PDBsum6mta
PubMed32187889
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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