Structure of PDB 6mdp Chain C

Receptor sequence

>6mdpC (length=527) Species: 10029 (Cricetulus griseus) [Search protein sequence]

IINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGIL
LYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFA
DAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSK
IDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQIL
HIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHI
IVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWG
DPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESN
FPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDY
VPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAF
STTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLL
MLIEMSLQMDPEYRVRKFLALLREEGA

3D structure

PDB

6mdp Structural principles of SNARE complex recognition by the AAA+ protein NSF.

Chain

Resolution

3.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.6.4.6: vesicle-fusing ATPase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	C	G342 S343 V346	G135 S136 V139
BS02	ATP	C	N505 G506 I507 I508 P545 H546 G548 T550 I707 K708	N294 G295 I296 I297 P334 H335 G337 T339 I496 K497
BS03	ATP	C	P262 G263 G265 K266 T267 L268 E329 N374 I406 G438 A439	P55 G56 G58 K59 T60 L61 E122 N167 I199 G231 A232
BS04	ATP	C	L355 D359 R385 R388	L148 D152 R178 R181

Gene Ontology

	Molecular Function
GO:0000149	SNARE binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016887	ATP hydrolysis activity
GO:0017075	syntaxin-1 binding
GO:0019901	protein kinase binding
GO:0019905	syntaxin binding
GO:0030165	PDZ domain binding
GO:0035255	ionotropic glutamate receptor binding
GO:0042802	identical protein binding
GO:0044877	protein-containing complex binding
GO:0046872	metal ion binding
GO:0140545	ATP-dependent protein disaggregase activity

	Biological Process
GO:0001921	positive regulation of receptor recycling
GO:0006813	potassium ion transport
GO:0006886	intracellular protein transport
GO:0006891	intra-Golgi vesicle-mediated transport
GO:0015031	protein transport
GO:0035494	SNARE complex disassembly
GO:0043001	Golgi to plasma membrane protein transport
GO:0045732	positive regulation of protein catabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005795	Golgi stack
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030496	midbody

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Molecular Function

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Cellular Component

External links

PDB	RCSB:6mdp, PDBe:6mdp, PDBj:6mdp
PDBsum	6mdp
PubMed	30198481
UniProt	P18708\|NSF_CRIGR Vesicle-fusing ATPase (Gene Name=NSF)

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