Structure of PDB 6li9 Chain C

Receptor sequence
>6li9C (length=623) Species: 9606 (Homo sapiens) [Search protein sequence]
QPYAGMPKEVLFQFSGQARYRIPREILFWLTVASVLVLIAATIAIIALSP
KCLDWWQEGPMYQIYPRSFKDSNKDGNGDLKGIQDKLDYITALNIKTVWI
TSFYKSSLKDFRYGVEDFREVDPIFGTMEDFENLVAAIHDKGLKLIIDFI
PNHTSDKHIWFQLSRTRTGKYTDYYIWHDCTHENGKTIPPNNWLSVYGNS
SWHFDEVRNQCYFHQFMKEQPDLNFRNPDVQEEIKEILRFWLTKGVDGFS
LDAVKFLLEAKHLRDEIQVNKTQIPDTVTQYSELYHDFTTTQVGMHDIVR
SFRQTMDQYSTEPGRYRFMGTEAYAESIDRTVMYYGLPFIQEADFPFNNY
LSMLDTVSGNSVYEVITSWMENMPEGKWPNWMIGGPDSSRLTSRLGNQYV
NVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYDINTLRSKSPMQWD
NSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANE
LLLNRGWFCHLRNDSHYVVYTRELDGIDRIFIVVLNFGESTLLNLHNMIS
GLPAKMRIRLSTNSADKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQTAF
RDRCFVSNRACYSSVLNILYTSC
3D structure
PDB6li9 Cryo-EM structure of the human heteromeric amino acid transporter b0,+AT-rBAT.
ChainC
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D210 S312 D314 E384 P448 D449
Catalytic site (residue number reindexed from 1) D148 S250 D252 E322 P386 D387
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C N214 D284 F318 L319 E321 N152 D222 F256 L257 E259
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015171 amino acid transmembrane transporter activity
GO:0015174 basic amino acid transmembrane transporter activity
GO:0015184 L-cystine transmembrane transporter activity
GO:0044877 protein-containing complex binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006865 amino acid transport
GO:0010467 gene expression
GO:0015802 basic amino acid transport
GO:0015810 aspartate transmembrane transport
GO:0015811 L-cystine transport
GO:0015813 L-glutamate transmembrane transport
GO:1990822 basic amino acid transmembrane transport
Cellular Component
GO:0005774 vacuolar membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6li9, PDBe:6li9, PDBj:6li9
PDBsum6li9
PubMed32494597
UniProtQ07837|SLC31_HUMAN Amino acid transporter heavy chain SLC3A1 (Gene Name=SLC3A1)

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