Structure of PDB 6lb5 Chain C

Receptor sequence
>6lb5C (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
DMPVERILEAELAVEPKTETYVEANDPVTNICQAADKQLFTLVEWAKRIP
HFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSA
HSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPA
EVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLF
FFKLIGDTPIDTFLMEMLEA
3D structure
PDB6lb5 Crystal structure of dimeric RXR-LBD complexed with full agonist NEt-3IB and TIF2 co-activator
ChainC
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C F277 V280 K284 V298 R302 T449 E453 F40 V43 K47 V61 R65 T212 E216
BS02 E80 C I268 A272 Q275 N306 L309 F313 R316 L326 C432 I31 A35 Q38 N69 L72 F76 R79 L89 C195 BindingDB: Ki=182nM,EC50=19nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6lb5, PDBe:6lb5, PDBj:6lb5
PDBsum6lb5
PubMed
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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